Advances in Diagnostic and Molecular Pathology

Recent advances in molecular pathology of craniopharyngioma

Craniopharyngiomas are rare epithelial tumours arising along the path of the craniopharyngeal duct. Two major histological subtypes have been recognised, the papillary and the adamantinomatous. Craniopharyngiomas remain challenging tumours to manage and are associated with significant morbidities and mortality. Recent advances in the molecular pathology of these neoplasms have identified BRAF m...

[New advances on diagnostic imaging in spinal pathology].

In the past years, there has been a remarkable improvement on imaging technology. Magnetic resonance (MR) is the method of choice for detection, diagnosis and therapeutic management for many disorders of the spine. A variety of innovative new MR methods have been developed. These new techniques include molecular diffusion sequences, MR myelography, a complete study of the entire spine, kinemati...

Advances in Molecular Pathology: Diagnosis, Prognosis, and Therapeutic Selection

Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers.

Over the past 10 years, there has been an increasing use of molecular markers in the assessment and management of adult malignant gliomas. Some molecular signatures are used diagnostically to help pathologists classify tumours, whereas others are used to estimate prognosis for patients. Most crucial, however, are those markers that are used to predict response to certain therapies, thereby dire...

Recent Advances in the Molecular Pathology of Bullous Skin Disorders

Maintenance of an intact epidermis depends on secure adhesion between adjacent keratinocytes and between basal keratinocytes and underlying epidermal basement membrane. The major adhesion units that achieve this are the hemidesmosomes and desmosomes but when these structures are disrupted, for example by gene mutations or autoantibodies, the resilience of the epidermis is lost and blisters deve...